Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases.

نویسندگان

  • Jing Xie
  • Seneca L Bessling
  • Timothy K Cooper
  • Harry C Dietz
  • Andrew S McCallion
  • Shannon Fisher
چکیده

RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

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عنوان ژورنال:
  • Genetics

دوره 176 2  شماره 

صفحات  -

تاریخ انتشار 2007